Our team brings together exceptional talent with a passion to explore uncharted territory and a laser focus on bringing new medicines to patients — with a sense of urgency.
Grow your expertise on problems that matter.
At Pinnacle Medicines, you'll work closely with scientists across the full spectrum of drug discovery - from chemistry and biology to formulation and CMC.
We've deliberately built a culture without silos because breakthroughs often happen at the interfaces between disciplines. Program updates, data, and decisions are shared openly across the company, and everyone — regardless of seniority — is encouraged to contribute and push the science forward.
For early-career researchers, this means sitting at the table from day one with access to the raw data, candid conversations, and the experience of those who've successfully brought new medicines to patients.
Breakthrough science runs on rigor and curiosity in equal measure. At Pinnacle, both are valued.
We are building a multidisciplinary team of scientists, engineers, and drug development experts advancing next-generation peptide therapeutics. Explore opportunities to contribute to our growing discovery and development programs.
Lead structural biology strategy to unlock the molecular design of next-generation peptide therapeutics. Read more
About the Role
This role will be responsible for developing and executing forward-looking protein science, structural biology and biophysics strategy. The ideal candidate will have a deep understanding of the unique characteristics of peptides as a therapeutic modality and accordingly position biophysics and structural biology as a key differentiator of our discovery platform. The candidate will have a clear perspective on how structural biology can be integrated with traditional structure-based design and emerging AI-based methods. The candidate will be part of the core discovery teams and effectively integrate biophysics and structural biology at all stages from hit ID to LO.
Responsibilities
Qualifications
Build AI and machine learning systems that power our next-generation peptide discovery platform. Read more
About the Role
We are seeking a creative and driven Machine Learning Engineer to help advance PinSilico—our AI and physics-powered peptide discovery platform. This role sits at the intersection of machine learning, computational chemistry, and scientific software engineering at the forefront of drug discovery. You will learn directly from seasoned drug hunters across chemistry, biology, and computation, gaining firsthand exposure to how new medicines are discovered and developed for patients. This is a high-impact, foundational hire shaping the core of our computational platform.
Responsibilities
Qualifications
Preferred
Lead quality and analytical development strategy for clinical-stage peptide therapeutics. Read more
About the Role
The Senior Director of Quality Assurance and Analytical Development is responsible for leading and executing QA strategy and analytical development activities to support the development and registration of oral and injectable drug products. This role ensures compliance with global regulatory standards (FDA, EMA, NMPA, ICH) while building robust analytical methods, stability programs, and quality systems across development and manufacturing. The candidate will be based in Doylestown, PA.
Quality Assurance (QA) Responsibilities
Analytical Development Responsibilities
Regulatory & CMC Support
Leadership & Strategy
Qualifications
Drive the development and GMP manufacturing of innovative oral peptide formulations. Read more
About the Role
We are seeking a Senior Director, Oral Formulation Process Development & Manufacturing to lead drug product process development and clinical GMP manufacturing activities for oral peptide programs at our Shanghai site. This role will provide strategic and technical leadership across CDMO partnerships to enable robust, scalable, and compliant manufacturing processes for complex oral peptide formulations. The ideal candidate brings deep expertise in oral dosage form development, strong hands-on manufacturing knowledge, and demonstrated success leading external partners through clinical manufacturing in a fast-paced biotech environment.
Responsibilities
Qualifications
Preferred Skills
Lead cross-functional program strategy across Pinnacle’s peptide discovery and development portfolio. Read more
About the Role
We are seeking a strategic and execution-focused Executive Director of Project Management to lead cross-functional program management across Pinnacle's peptide discovery and development portfolio. This individual will serve as a core member of the development leadership team and will be responsible for driving integrated program strategy, governance, timelines, and resource alignment from early discovery through IND-enabling activities and into early clinical development. The ideal candidate brings deep experience managing complex drug development programs in biotech environments and has demonstrated success aligning scientific, regulatory, CMC, and external partner functions to deliver milestone-driven outcomes. The position will be reporting to the Head of Translational Science.
Responsibilities
Qualifications
Preferred Skills
Lead pharmacokinetics and drug metabolism strategy across a growing peptide pipeline. Read more
About the Role
We are seeking a highly motivated and experienced Senior Director of DMPK at our Doylestown, PA site. The candidate will work within the discovery team and be responsible for ADME/DMPK aspects of all of our peptide discovery and development pipeline, including lead identification/optimization, FIH translation, and non-clinical packages to support regulatory filings. The candidate must have demonstrated an ability to work collaboratively in a fast-paced, dynamic environment with excellent scientific and communication skills. The position will be reporting to the Head of Translational Science.
Responsibilities
Qualifications
Preferred Skills
Shape nonclinical safety strategy for next-generation peptide therapeutics. Read more
About the Role
We are seeking a strategic and scientifically rigorous Senior Director of Toxicology to lead nonclinical safety strategy across Pinnacle's peptide development portfolio. This role will be responsible for designing and executing toxicology programs to support IND-enabling studies, regulatory submissions, and early clinical development. The successful candidate will serve as the nonclinical safety lead on project teams and will work closely with DMPK, Bioanalytics, and Regulatory to ensure comprehensive and risk-mitigated development strategies. The position will be reporting to the Head of Translational Science.
Responsibilities
Qualifications
Preferred Skills
Lead bioanalytical strategy supporting pharmacokinetics, toxicology, and translational science. Read more
About the Role
We are seeking a highly experienced Senior Director of Bioanalytics to lead bioanalytical strategy and execution across Pinnacle's peptide discovery and development programs. This role will be responsible for establishing and overseeing bioanalytical platforms to support pharmacokinetics, toxicology, and translational studies from discovery through clinical development. The candidate will play a critical role in assay development, method validation, and regulatory-compliant bioanalysis to enable robust PK/PD characterization and regulatory submissions. The position will be reporting to the Head of Translational Science.
Responsibilities
Qualifications
Preferred Skills
At Pinnacle Medicines, we believe the people advancing our science should feel supported in every part of their lives. Our benefits program is designed to promote health, financial security, and work-life balance.
Benefits highlights:
We are growing and continuously seeking outstanding talent. If you do not see an open role that fits your background today, please email [email protected] and share how you could help us build a leading peptide discovery company.