A therapeutic modality that combines the best attributes of small molecules and biologics. Our discovery platform is designed to develop peptides with exceptional affinity, specificity, metabolic stability, and optimal PK. We are also leveraging state-of-the-art oral formulation to achieve antibody-like efficacy with a pill.
PinPoint - peptide specific medicinal chemistry approach.
PinSilico - A breakthrough suite of SBDD integrating physics and AI
PinPoint powered by PinSilico enables rapid progression of a hit to a candidate
At the core of our discovery engine is PinPoint - a peptide-specific medicinal chemistry approach designed to engineer drug-like properties into validated hits. PinPoint combines structural biology with bespoke non-canonical amino acid design to identify and exploit promising receptor interactions to transform a hit peptide into a candidate.
PinPoint is powered by PinSilico - a breakthrough suite of structure-based drug design (SBDD) technologies that integrates physics-based simulations, emerging AI methodologies, and scalable computational infrastructure. PinSilico allows rapid hit diversification and lead optimization for tuning affinity and phys-chem properties. PinSilico includes PinFormatics and PinScale as a foundation on which we have built PinFinity and PinNovo workflows with more on the way.
De novo peptide design
PinNovo combines AI models for structure prediction, physics-based simulations and automated non-canonical amino acid design to generate diverse site-specific cyclic peptide binders with activity profile comparable with in vitro affinity based screening.
Binding optimization & structure refinement
PinFinity focuses on enhancing target engagement through iterative structure-guided optimization. Using simulation-driven feedback loops, it refines binding affinity, conformational stability, and interaction specificity.
Cheminformatics and data intelligence tailored to peptides
PinFormatics marries custom cheminformatics with experimental and computational data streams, enabling seamless SAR analysis across sequence and chemical structure space, generating insights from historical data and accelerating design.
Computational scale & workflow automation
PinScale is the high-performance distributed computing backbone of the whole platform. Through automated workflows built on scalable compute infrastructure, it accelerates DMTA cycles and the number of targets with SBDD-enabled series.
PinPoint - peptide specific medicinal chemistry approach.
PinSilico - A breakthrough suite of SBDD integrating physics and AI
PinPoint powered by PinSilico enables rapid progression of a hit to a candidate